Atracurium besylate
Atracurium Besylate (atracurium besylate) is a small molecule pharmaceutical. Atracurium besylate was first approved as Tracrium preservative free on 1983-11-23.
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Trade Name
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Atracurium besylate (discontinued: Atracurium besylate, Tracrium)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| atracurium besylate | ANDA | 2024-12-04 |
Indications
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Clinical
Clinical Trials
156 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | — | 3 | 4 | 8 | 9 | 21 |
| Anesthesia | D000758 | — | — | — | — | — | 3 | 7 | 10 |
| Neuromuscular blockade | D019148 | — | — | — | — | — | 1 | 8 | 9 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | — | 2 | 3 | 5 |
| Delirium | D003693 | — | R41.0 | — | — | — | 1 | 3 | 4 |
| Emergence delirium | D000071257 | — | — | — | — | — | 1 | 3 | 4 |
| Acute pain | D059787 | — | R52 | — | — | — | 1 | 3 | 4 |
| Muscle relaxation | D009126 | — | — | — | 2 | 2 | 1 | 1 | 4 |
| Premedication | D011292 | — | — | — | 2 | 2 | 1 | — | 3 |
| General anesthesia | D000768 | — | — | — | — | — | 1 | 2 | 3 |
Show 35 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypospadias | D007021 | EFO_0004209 | Q54 | — | 1 | 1 | — | 2 | 3 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | — | 2 | 3 |
| Intratracheal intubation | D007442 | — | — | — | 2 | 2 | — | — | 2 |
| Inguinal hernia | D006552 | HP_0000023 | K40 | — | 1 | 1 | — | 1 | 2 |
| Hernia | D006547 | — | K40-K46 | — | 1 | 1 | — | 1 | 2 |
| Cerebral infarction | D002544 | — | I63 | — | 1 | 1 | — | — | 1 |
| Hyperalgesia | D006930 | — | — | — | — | 1 | — | — | 1 |
| Gastrointestinal diseases | D005767 | — | — | — | 1 | 1 | — | — | 1 |
| Cholecystitis | D002764 | — | K81 | — | 1 | 1 | — | — | 1 |
| Abdominal hernia | D046449 | — | K46 | — | 1 | 1 | — | — | 1 |
Show 5 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 2 | — | — | 1 | 3 |
| Acute lung injury | D055371 | EFO_0004610 | — | — | 2 | — | — | 1 | 3 |
| Hypothermia | D007035 | — | T68 | — | 2 | — | — | 1 | 3 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | — | 2 | — | — | 1 | 3 |
| Covid-19 | D000086382 | — | U07.1 | — | 1 | — | — | 1 | 2 |
| Chronic pain | D059350 | — | — | 1 | 1 | — | — | 1 | 2 |
| Delayed emergence from anesthesia | D055191 | — | — | 1 | 1 | — | — | 1 | 2 |
| Radical mastectomy | D015409 | — | — | 1 | 1 | — | — | — | 1 |
| Replacement arthroplasty knee | D019645 | — | — | — | 1 | — | — | — | 1 |
| Orthopedic procedures | D019637 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | — | N19 | — | — | — | — | 3 | 3 |
| Vomiting | D014839 | — | R11.1 | — | — | — | — | 3 | 3 |
| Nausea | D009325 | — | R11.0 | — | — | — | — | 3 | 3 |
| Epidural anesthesia | D000767 | — | — | — | — | — | — | 2 | 2 |
| Fistula | D005402 | — | — | — | — | — | — | 2 | 2 |
| Agnosia | D000377 | EFO_0007136 | F88 | — | — | — | — | 2 | 2 |
| Neuralgia | D009437 | EFO_0009430 | — | — | — | — | — | 2 | 2 |
| Postoperative complications | D011183 | — | — | — | — | — | — | 2 | 2 |
| Cleft lip | D002971 | EFO_0003959 | Q36 | — | — | — | — | 1 | 1 |
| Nephrectomy | D009392 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Atracurium besylate |
| INN | atracurium besilate |
| Description | Atracurium besylate is the bisbenzenesulfonate salt of atracurium. It has a role as a nicotinic antagonist and a muscle relaxant. It is a quaternary ammonium salt and an organosulfonate salt. It contains an atracurium. |
| Classification | Small molecule |
| Drug class | quaternary ammonium derivatives: neuromuscular blocking agents |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC.O=S(=O)([O-])c1ccccc1.O=S(=O)([O-])c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 64228-81-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200527 |
| ChEBI ID | 2915 |
| PubChem CID | 47320 |
| DrugBank | DB00732 |
| UNII ID | 40AX66P76P (ChemIDplus, GSRS) |
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Safety
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Adverse Events
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2,104 adverse events reported
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