Atracurium besylate
Atracurium Besylate (atracurium besylate) is a small molecule pharmaceutical. Atracurium besylate was first approved as Tracrium preservative free on 1983-11-23.
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Commercial
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Trade Name
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Atracurium besylate (discontinued: Atracurium besylate, Tracrium)
Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| atracurium besylate | ANDA | 2023-11-23 |
Indications
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Agency Specific
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Clinical
Clinical Trials
156 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | — | — | 1 | 8 | 7 | 16 |
| Anesthesia | D000758 | — | — | — | — | — | 3 | 8 | 11 |
| Neuromuscular blockade | D019148 | — | — | — | — | — | 1 | 9 | 10 |
| General anesthesia | D000768 | — | — | — | — | — | 1 | 5 | 6 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | — | 2 | 3 | 5 |
| Vomiting | D014839 | HP_0002013 | R11.1 | — | — | — | 2 | 3 | 5 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 2 | — | 2 | 1 | 5 |
| Acute lung injury | D055371 | EFO_0004610 | — | — | 2 | — | 2 | 1 | 5 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | — | 2 | — | 2 | 1 | 5 |
| Acute pain | D059787 | — | R52 | — | — | — | 1 | 3 | 4 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypospadias | D007021 | EFO_0004209 | Q54 | — | 1 | 1 | — | 2 | 3 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | — | 2 | 3 |
| Intratracheal intubation | D007442 | — | — | — | 2 | 2 | — | — | 2 |
| Cerebral infarction | D002544 | — | I63 | — | 1 | 1 | — | — | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | — | 1 | — | — | 1 |
| Hyperalgesia | D006930 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypothermia | D007035 | HP_0002045 | T68 | — | 2 | — | — | 2 | 4 |
| Covid-19 | D000086382 | — | — | — | 1 | — | — | 1 | 2 |
| Chronic pain | D059350 | HP_0012532 | — | 1 | 1 | — | — | 1 | 2 |
| Radical mastectomy | D015409 | — | — | 1 | 1 | — | — | — | 1 |
| Replacement arthroplasty knee | D019645 | — | — | — | 1 | — | — | — | 1 |
| Orthopedic procedures | D019637 | — | — | — | 1 | — | — | — | 1 |
| Hip prosthesis | D006622 | — | — | — | 1 | — | — | — | 1 |
| Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | — | — | 1 | — | — | — | 1 |
| Intraocular pressure | D007429 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | — | — | 3 | 3 |
| Laparoscopic cholecystectomy | D017081 | — | — | — | — | — | — | 3 | 3 |
| Nausea | D009325 | HP_0002018 | R11.0 | — | — | — | — | 3 | 3 |
| Intravenous anesthesia | D000771 | — | — | — | — | — | — | 3 | 3 |
| Epidural anesthesia | D000767 | — | — | — | — | — | — | 2 | 2 |
| Fistula | D005402 | — | — | — | — | — | — | 2 | 2 |
| Electroencephalography | D004569 | — | — | — | — | — | — | 2 | 2 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | — | — | — | 2 | 2 |
| Neuralgia | D009437 | EFO_0009430 | — | — | — | — | — | 2 | 2 |
| Postoperative complications | D011183 | — | — | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Atracurium besylate |
| INN | atracurium besilate |
| Description | Atracurium besylate is the bisbenzenesulfonate salt of atracurium. It has a role as a nicotinic antagonist and a muscle relaxant. It is a quaternary ammonium salt and an organosulfonate salt. It contains an atracurium. |
| Classification | Small molecule |
| Drug class | quaternary ammonium derivatives: neuromuscular blocking agents |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC.O=S(=O)([O-])c1ccccc1.O=S(=O)([O-])c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 64228-81-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200527 |
| ChEBI ID | 2915 |
| PubChem CID | 47320 |
| DrugBank | DB00732 |
| UNII ID | 40AX66P76P (ChemIDplus, GSRS) |
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Additional graphs summarizing 351 documents
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Safety
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Adverse Events
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1,844 adverse events reported
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